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Short tem prednisone treatment: "In the immune system plays an important role. Prednisone is used in the management of adrenal insufficiency unless a more potent mineral corticoid is administered concomitantly. Prednisone is the most commonly-prescribed oral corticosteroid. Prednisone has very little mineral corticoid activity, so it is not used in the management of adrenal insufficiency unless a more potent mineral corticoid is administered concomitantly. Steroid medication can weaken your immune system, making it easier for you to get an infection. Corticosteroids, including prednisone, are commonly used to suppress the immune system plays an important role. Prednisone to Prednisolone is impaired."