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The body, and so reduces the heart's need for oxygen, which means it can also be used in the management of angina. If you have ischemic heart disease. Propranolol should be administered with caution since it may block bronchodilation produced by endogenous and exogenous catecholamine stimulation of beta-adrenergic receptors. You have ischemic heart disease. Propranolol is a competitive antagonist which specifically competes with beta-adrenergic receptor stimulating agents for available beta-receptor sites. The active ingredient Propranolol hydrochloride, which is a type of medicine called a beta-blocker. Treatment with Propranolol, laboratory determinations should be made at regular intervals. You have ischemic heart disease.